The site is secure. Influence of storage temperature on indomethacin release from Do not give this medicine (promethazine suppositories) to a child who is throwing up for an unknown reason. Usual Pediatric Dose for Nausea/Vomiting. Do not freeze. endobj Files, Presentations suppository. FOIA PRECAUTIONSDrug Interactions). FDA Safety Recalls, Store promethazine tablets, oral solution, and solution for injection at room temperature between 68 - 77F and protect from light. This method is capable of distinguishing the intact drug from its thermal and photodegradation products. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. endobj A linear relationship between peak height ratio (promethazine-promazine) and promethazine concentration is found up to a concentration of 600 micrograms/ml. Privacy Policy | Copyright 2023. Dermographism. Store promethazine suppositories in the refrigerator. WebPromethazine HCl 25mg. 301-657-3000. PubMed, WebRefrigerated medications should be stored at temperatures between 2oC and 8oC (35oF to 46oF). This site complies with the HONcode standard for trustworthy health information: verify here. Store suppositories in a refrigerator. A WIDE RANGE OF WEIGHT-BASED DOSES OF PROMETHAZINE HCl SUPPOSITORIES HAVE RESULTED IN RESPIRATORY DEPRESSION IN THESE PATIENTS. Household teaspoons may not be an accurate measuring device. ). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Promethazine This method is capable of distinguishing the intact drug from its thermal and photodegradation products. The release of indomethacin from fatty-base suppositories, which had been stored at a low (4 degrees C) and a high (25-30 degrees C) temperature for about one month, was examined in vitro and in vivo. Pediatric patients should be supervised to avoid potential harm in bike riding or other hazardous activities. 4 0 obj Throw away unused or expired drugs. Perennial and seasonal allergic rhinitis. CNS Depressants Promethazine HCl Suppositories may increase, prolong, or intensify the sedative action of other central-nervous-system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving promethazine HCl. In vivo and in vitro release of indomethacin from water-soluble and fatty base suppositories. Comments: Oral or Rectal: 25 to 50 mg orally or rectally once For children, Promethazine HCl Rectal Suppositories, 12.5 to 25 mg, twice daily, may be administered. Sedating drugs may cause confusion and over-sedation in the elderly; elderly patients generally should be started on low doses of promethazine HCl suppositories and observed closely. Mild, uncomplicated allergic skin manifestations of urticaria and angioedema. 1978 Feb;30(2):75-80. doi: 10.1111/j.2042-7158.1978.tb13165.x. Promethazine HCl 25mg. Promethazine HCl Suppositories are for rectal administration only. Nonteratogenic Effects To view updated drug label links, paste the RSS feed address (URL) shown below into a RSS reader, or use a browser which supports RSS feeds, such as Safari for Mac OS X. Minor transfusion and/or amelioration of allergic reactions may be controlled with 12.5 mg doses. Allergy The average dose is 25 mg taken before retiring; however, 12.5 mg may be taken before meals and on retiring, if necessary. If your symptoms or health problems do not get better or if they become worse, call your doctor. J Pharm Pharmacol. View NDC Code(s)NEW! Note that any depressant effects of promethazine HCl are not reversed by naloxone. Promethazine should not be given to babies or children who are younger than 2 years old and should be given with caution to children who are 2 years of age or older. However, many people have no side effects or only have minor side effects. Keep all drugs out of the reach of children and pets. Stay informed and get access to the latest news, 4500 East-West Highway, Teratogenic Effects - Pregnancy Category C A wide range of weight-based doses have resulted in respiratory depression in these patients. WebPromethazine HCL Suppository, Rectal - Uses, Side Effects, and More Common Brand(S): Phenergan, Promethegan Generic Name(S): promethazine View Free Coupon Monoamine Oxidase Inhibitors (MAOI) Keep containers out of reach of children and pets. Development and validation of a HPLC method for the analysis of promethazine hydrochloride in hot-melt extruded dosage forms. It may be given to you for other reasons. Store them away from light, heat, and moisture. Unable to load your collection due to an error, Unable to load your delegates due to an error. Promethazine HCl Suppositories, USP are useful for: Do not take more or less of it or take it more often than prescribed by your doctor. Promethazine is used with other medications to treat anaphylaxis (sudden, severe allergic reactions) and the symptoms of the common cold such as sneezing, cough, and runny nose. Promethazine HCl Suppositories may lower seizure threshold. Maximum dose: 25 Generic name: Promethazine Suppositories [proe-METH-a-zeen] to make sure that it is safe for you to take this medicine (promethazine suppositories) with all of your drugs and health problems. Events, Do not take 2 doses at the same time or extra doses. The melting point of suppositories stored at a high temperature was higher by approximately 2 degrees C than those stored at a low temperature. Atropine-like signs and symptoms-dry mouth, fixed, dilated pupils, flushing, as well as gastrointestinal symptoms-may occur. Phenergan - Food and Drug Administration We anticipate reposting the images once we are able identify and filter out images that do not match the information provided in the drug labels. 8600 Rockville Pike Administered IV as an adjunct to anesthesia or analgesia with reduced amounts of meperidine of other narcotic analgesics in special surgical situations (e.g., repeated bronchoscopy, ophthalmic surgery, poor-risk patients), Therapy adjunctive to meperidine or other analgesics for control of postoperative pain. Talk with the doctor. Parenteral: 12.5 mg IM or IV once, and may be repeated within 2 hours if necessary Epinephrine Because of the potential for promethazine HCl to reverse epinephrines vasopressor effect, epinephrine should NOT be used to treat hypotension associated with Promethazine HCl Suppositories overdose. Promethazine: MedlinePlus Drug Information Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery. Neuroleptic malignant syndrome (potentially fatal) has also been reported (See Although antihistamines have been found to produce fetal mortality in rodents, the pharmacological effects of histamine in the rodent do not parallel those in man.